:root { color-scheme: light; --site-ink: #1d1d1f; --site-muted: #53616d; --site-accent: #087c72; --site-line: #e2e7e9; }
html { scroll-behavior: smooth; }
body { background: #f5f5f7; color: var(--site-ink); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif; }
a:focus-visible, button:focus-visible, input:focus-visible, textarea:focus-visible { outline: 3px solid #60b6e8; outline-offset: 2px; }
.page-container { max-width: 1280px; }
.title-background { background: linear-gradient(120deg, #0a605a, #179e88) !important; padding: 17px 0 !important; margin-bottom: 15px; }
.main-title { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: clamp(30px, 3vw, 40px) !important; letter-spacing: -.04em; }
.sub-title { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: clamp(14px, 1.7vw, 19px) !important; line-height: 1.4 !important; max-width: 980px; }
.nav-container { gap: 4px; padding: 9px 12px; background: #fff; border: 1px solid var(--site-line); border-radius: 16px; box-shadow: 0 8px 26px rgba(30, 50, 60, .045); }
.nav-container .nav-link { display: inline-flex; align-items: center; justify-content: center; gap: 5px; min-width: 0; margin: 2px; padding: 9px 12px; color: #3e4c57; border-radius: 9px; background: transparent; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 14px !important; font-weight: 650 !important; line-height: 1.2; letter-spacing: 0; text-decoration: none; }
.nav-container .nav-link:hover { background: #eef5f3; color: #006e65; }
.nav-container .nav-link.active { background: #e3f3ee; color: #006e65; }
.nav-container .nav-link i { font-size: 13px; width: auto; margin: 0; }
.nav-account-form { align-items: stretch; }
.nav-account-form button.nav-account-button { font-size: 14px !important; font-weight: 650 !important; background: transparent; border: 0; cursor: pointer; }
.content-eyebrow { color: #006d63; font-size: 11px; font-weight: 760; letter-spacing: .13em; }
.site-button, .site-button-secondary { display: inline-flex; align-items: center; justify-content: center; gap: 9px; min-height: 42px; padding: 10px 17px; border-radius: 10px; font-size: 14px; font-weight: 700; line-height: 1.3; text-decoration: none; transition: transform .15s ease, background-color .15s ease; }
.site-button { color: #fff; background: #087c72; border: 1px solid #087c72; }
.site-button:hover { color: #fff; background: #006b63; transform: translateY(-1px); }
.site-button-secondary { color: #006d63; background: #fff; border: 1px solid #bed1cd; }
.site-button-secondary:hover { background: #edf7f4; transform: translateY(-1px); }
.news-teaser { width: 100%; display: grid; grid-template-columns: 142px minmax(0, 1fr); gap: 27px; align-items: center; margin: 24px 0 30px !important; padding: 20px; text-align: left; background: #fff; border: 1px solid var(--site-line); border-radius: 20px; box-shadow: 0 12px 32px rgba(25, 37, 44, .04); }
.news-teaser img { display: block; width: 142px; height: 150px; object-fit: cover; object-position: top; border-radius: 12px; }
.news-teaser h2 { margin: 8px 0; font-size: clamp(21px, 2.5vw, 30px); letter-spacing: -.035em; line-height: 1.2; }
.news-teaser p { color: var(--site-muted); margin: 0 0 17px; line-height: 1.55; }
.news-main { width: 100%; padding: 32px 0 65px; }
.news-feature { display: grid; grid-template-columns: minmax(0, 1fr) minmax(260px, 400px); gap: clamp(25px, 5vw, 70px); align-items: center; padding: clamp(24px, 5vw, 58px); background: #fff; border: 1px solid var(--site-line); border-radius: 22px; box-shadow: 0 14px 40px rgba(25, 37, 44, .045); }
.news-feature h2 { font-size: clamp(32px, 4.5vw, 57px); line-height: 1.08; letter-spacing: -.05em; margin: 16px 0 22px; }
.news-feature p { color: #46535f; font-size: 17px; line-height: 1.65; }
.news-feature > img { display: block; width: 100%; height: auto; max-height: 550px; object-fit: contain; border-radius: 13px; box-shadow: 0 16px 38px rgba(16, 38, 38, .14); }
.citation-main { width: 100%; max-width: 1000px; padding: 35px 0 60px; }
.citation-heading { width: 100%; text-align: left; }
.citation-heading h2 { margin: 8px 0; font-size: clamp(32px, 4vw, 45px); letter-spacing: -.05em; }
.citation-heading p { margin: 0 0 23px; color: #46535f; font-size: 16px; }
.citation-box { width: 100%; padding: clamp(22px, 4vw, 38px); border-color: var(--site-line); border-radius: 20px; box-shadow: 0 12px 32px rgba(25, 37, 44, .04); }
.citation-box .citation-title { color: #006d63; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 12px !important; letter-spacing: .1em; text-transform: uppercase; }
.citation-box .citation-reference { color: #283742; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 17px !important; line-height: 1.72; text-align: left; overflow-wrap: anywhere; }
.citation-box .citation-reference a { color: #006d63; text-underline-offset: 3px; }
.citation-actions { display: flex; flex-wrap: wrap; gap: 11px; margin-top: 20px; }
.home-citation { width: 100%; box-sizing: border-box; margin: 16px 0 45px; padding: clamp(22px, 3vw, 32px); background: #fff; border: 1px solid var(--site-line); border-radius: 18px; box-shadow: 0 10px 30px rgba(25, 37, 44, .04); text-align: left; }
.home-citation h2 { margin: 8px 0 12px; color: var(--site-ink); font-size: clamp(21px, 2.5vw, 28px); letter-spacing: -.035em; }
.home-citation p { margin: 0; color: #354450; font-size: 15px; line-height: 1.75; overflow-wrap: anywhere; }
.home-citation a { color: #006d63; text-underline-offset: 3px; }
.predict-main { width: 100%; }
.predict-usage-banner { width: 100%; display: flex; justify-content: space-between; align-items: center; gap: 25px; margin: 18px 0 24px; padding: 24px 27px; background: #fff; border: 1px solid var(--site-line); border-radius: 18px; box-shadow: 0 10px 30px rgba(25, 37, 44, .04); }
.predict-usage-banner h2 { margin: 5px 0 8px; font-size: clamp(22px, 2.5vw, 29px); letter-spacing: -.035em; }
.predict-usage-banner p { max-width: 730px; margin: 0; color: #46535f; font-size: 14px; line-height: 1.6; }
.usage-actions { flex: 0 0 260px; display: grid; gap: 9px; }
.usage-actions a { width: 100%; text-align: center; }
.guidance-account-note { width: 100%; display: flex; align-items: center; justify-content: space-between; gap: 24px; margin: 25px 0 10px; padding: 25px 28px; background: #fff; border: 1px solid var(--site-line); border-radius: 18px; box-shadow: 0 10px 30px rgba(25, 37, 44, .04); box-sizing: border-box; }
.guidance-account-note h2 { margin: 6px 0 9px; color: var(--site-ink); font-size: clamp(22px, 2.5vw, 29px); letter-spacing: -.035em; }
.guidance-account-note p { max-width: 780px; margin: 0; color: #46535f; font-size: 14px; line-height: 1.65; }
.guidance-account-note .site-button { flex: none; }
.guidance-main .model-instruction, .guidance-main .fasta-instruction-1, .guidance-main .fasta-instruction-2 { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; color: #23313d; letter-spacing: -.025em; }
.guidance-main .model-instruction { margin-top: 30px; font-size: 20px !important; }
.guidance-main .fasta-instruction-1, .guidance-main .fasta-instruction-2 { font-size: 22px !important; }
.guidance-main .guidance-box { padding: 24px; border-color: var(--site-line); border-radius: 17px; box-shadow: 0 8px 25px rgba(25, 37, 44, .035); }
.guidance-main .guidance-list li, .guidance-main .notice-section, .guidance-main .notice-list li { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; color: #354450; font-size: 15px !important; line-height: 1.7; }
.guidance-main .notice-section { font-weight: 700 !important; }
.guidance-main .predict-link, .guidance-main .download-link, .guidance-main .github-link { color: #006d63 !important; }
#prediction-form.card { padding: clamp(20px, 3vw, 34px); border-color: var(--site-line); border-radius: 18px; box-shadow: 0 10px 30px rgba(25, 37, 44, .04); box-sizing: border-box; }
#prediction-form .form-group label { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 16px !important; font-weight: 700 !important; line-height: 1.5; color: #263742; }
#prediction-form .multi-select-display, #prediction-form .fasta-input, #prediction-form .custom-file-upload { border-color: #cedbd8; border-radius: 10px; }
#prediction-form .multi-select-display { min-height: 49px; }
#prediction-form .multi-select-display:hover { border-color: #087c72; }
#prediction-form .selected-tag { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 14px; font-weight: 600; color: #075e57; background: #e7f4f0; border-color: #d0e9e2; border-radius: 7px; }
#prediction-form .remove-tag { color: #087c72; font-family: inherit; font-size: 19px; }
#prediction-form .dropdown-option { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 15px; }
#prediction-form .dropdown-option.select-all-option { color: #006d63; }
#prediction-form .fasta-input { padding: 15px; font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace !important; font-size: 14px !important; line-height: 1.55; box-sizing: border-box; }
.predict-input-note { margin: 9px 0 0; color: #53616d; font-size: 13px; line-height: 1.6; }
#prediction-form .file-upload-btn { color: #006d63; font-size: 14px !important; }
#prediction-form .file-name-display { color: #53616d; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 14px !important; font-style: normal; }
#prediction-form .button-container { flex-wrap: wrap; gap: 10px; }
#prediction-form #predict-button, #prediction-form #example-button, #prediction-form #reset-button { width: auto; min-width: 112px; height: 44px; padding: 0 20px; border-radius: 10px; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; font-size: 15px !important; font-weight: 700 !important; box-shadow: none; transition: background-color .15s ease, transform .15s ease; }
#prediction-form #predict-button { color: #fff; background: #087c72; border: 1px solid #087c72; }
#prediction-form #predict-button:hover { color: #fff; background: #006b63; border: 1px solid #006b63; transform: translateY(-1px); }
#prediction-form #example-button, #prediction-form #reset-button { color: #006d63; background: #fff; border: 1px solid #bed1cd; }
#prediction-form #example-button:hover, #prediction-form #reset-button:hover { color: #005c54; background: #edf7f4; border: 1px solid #9fc5ba; transform: translateY(-1px); }
.results-container h2, .results-container .chart-title, .selection-label, .threshold-ptm-label, .threshold-btn, .chart-button, .download-button { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif !important; }
.selection-label, .threshold-ptm-label { color: #075e57; background: #e7f4f0; font-size: 15px; }
.selection-group { border-color: #d3dfdc; border-radius: 11px; background: #fbfdfc; }
.threshold-btn { font-size: 14px; font-weight: 700; padding: 8px 14px; }
.chart-button { font-size: 14px !important; border-radius: 9px; }
.chart-button.active { background: #087c72; border-color: #087c72; }
.download-button { font-size: 16px; border-radius: 10px; }
@media (max-width: 850px) {
  .predict-usage-banner { flex-direction: column; align-items: stretch; }
  .usage-actions { flex: auto; display: flex; flex-wrap: wrap; }
  .usage-actions a { width: auto; }
  .news-feature { grid-template-columns: 1fr; }
  .news-feature > img { max-width: 380px; margin: auto; }
  .guidance-account-note { flex-direction: column; align-items: stretch; }
  .guidance-account-note .site-button { align-self: flex-start; }
}
@media (max-width: 600px) {
  .page-container { padding: 0 15px; }
  .nav-container { padding: 7px; }
  .nav-container .nav-link { font-size: 13px !important; padding: 8px 9px; }
  .nav-container .nav-link i { display: none; }
  .news-teaser { grid-template-columns: 75px minmax(0, 1fr); gap: 14px; padding: 14px; }
  .news-teaser img { width: 75px; height: 100px; }
  .news-teaser h2 { font-size: 20px; }
  .news-teaser p { font-size: 13px; }
  .news-feature { padding: 23px; }
  .news-feature p { font-size: 15px; }
  .predict-usage-banner { padding: 20px; }
  .usage-actions { display: grid; }
  .usage-actions a { width: 100%; }
  .guidance-account-note { padding: 20px; }
  .guidance-account-note .site-button { align-self: stretch; }
  .guidance-main .guidance-box { padding: 18px; }
  #prediction-form #predict-button, #prediction-form #example-button, #prediction-form #reset-button { flex: 1 1 100px; }
}
@media (prefers-reduced-motion: reduce) { html { scroll-behavior: auto; } .site-button, .site-button-secondary { transition: none; } }